Excellence Award Winner (Clinical Research Category)


Excellence Award (Clinical Research Category) Recipient’s Remarks

Shun Yamashita, MD

Saga University Hospital

I would like to express my gratitude for selecting my research entitled “External validation of a clinical prediction model for infective endocarditis among patients with undiagnosed fever: A multi-center retrospective study” as an award for excellence in the section of Clinical Research at the American College of Physicians (ACP) Japan chapter annual meeting & lecture session 2023. I have seen that many notable doctors received various awards at the same annual meeting. I have kept in mind “one day, I want to achieve an award the meeting, too”, with yearning and awe for the award at the same meeting. It is my great pleasure to be selected to the award for excellence, making me feel as if I could have also joined in one of such doctors.

It can be difficult to diagnose Infective endocarditis (IE), the subject of this study. I have experienced many IE cases as follows: a case with disturbance of consciousness after surgery, who was diagnosed with IE after a short while; a case that could be diagnosed only by open-heart surgery; and cases that it became difficult to diagnose with IE due to the administration of antibiotics prior to obtaining blood culture samples. Among them, a case with a bad experience for me was included. I believe that the difficulty of diagnosing IE is owing to lack of the measures to estimate the probability of IE as early as possible after the patient’s admission, making the difference between doctors of the decision whether IE can be suspected in clinical settings. Therefore, we conducted a single-center study at a university hospital in Japan as a previous study and developed a prediction model for IE using only indicators that can be easily obtained even at hospitals without advanced medical equipment. In this study at four university hospitals, the external validation of the model also showed the excellent accuracy. In the future, I would like to clarify whether our model can be applied to multiple institutions, including community hospitals in Japan.

The quality of all research, presented as candidates for the Kurokawa Award other than my research, were very high. The question-and-answer sessions in English by those presenters were also excellent and overwhelmed me. I am very grateful to have been given such a honorable opportunity. I would also like to express my gratitude for the following hospitals joined in this research team: the Department of Diagnostic and Generalist Medicine, Dokkyo Medical University; the Department of General Medicine, Faculty of Medicine, Juntendo University; and the Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital. I will continue to devote myself to contribute to improve the quality of future medical care. Thank you very much.



ACP日本支部年次総会・講演会2023 一般演題優秀賞(臨床研究部門)を受賞して
佐賀大学総合診療科 山下 駿

この度は、米国内科学会(ACP)日本支部 年次総会・講演会2023において、私の研究演題“External validation of a clinical prediction model for infective endocarditis among patients with undiagnosed fever: A multi-center retrospective study”を臨床研究部門の優秀賞に選出していただき、誠にありがとうございました。これまで、名だたる先生方がACP日本支部 年次総会・講演会でさまざまな賞を受賞される姿を目の当たりにしてきました。同会での受賞に憧れと畏敬の念を抱き、「いつか自分も」と思い続けてきました。今回、優秀賞に選出していただき、そのような先生方の仲間入りができたような気がして、大変光栄です。


私の他に、黒川賞候補演題として発表された演題はどれも非常に質の高いものでした。発表者の英語による質疑応答も素晴らしいもので、圧倒されてしまいましたが、このような素晴らしい機会を与えていただけたことに感謝の気持ちでいっぱいです。また、本研究にご協力いただいた、獨協医科大学総合診療科、順天堂大学附属順天堂医院総合診療科、東邦大学医療センター大森病院 総合診療・急病センターの先生方には、この場をお借りして御礼を申し上げます。引き続き、未来の医療の質の向上に貢献できるよう、精進を続けていきたいと思います。この度は、本当にありがとうございました。


Special Award Winner (Medical Student )


Special Award (Medical Student ) Recipient’s Remarks

Ryuto Ohashi

International University of Health and Welfare

I am deeply honored to have received the Special Award for Medical Student at the ACP Japan Chapter 2023 Annual Meeting. Under the title of “Successful Preventive Strategies for COVID-19 at the Interactive Festival in Shibuya, Tokyo.”, I presented the infection control measures implemented at the interactive festival called “Shibuya Zunchaka!” held on September 3-4, 2022, in Shibuya, Tokyo as the case report.

During that time, amidst the seventh wave of COVID-19, the Emergency Statement was declared in Tokyo, leading to the cancellation of numerous cultural events including music festivals. However, by assuming that meticulous evidence-based preventive measures would enable the safe conduct of interactive events, we executed the event. As a result, despite the attendance of 20,000 individuals, we successfully avoided any new infections during and after the event.

Nevertheless, I acknowledge that this case report might not yield immediate impact. This is due to the rarity of a pandemic as significant as COVID-19, which occurs only once every century. Thus, the true purpose of this case report lies in serving as a precedent, demonstrating that “with proper infection control measures, interactive events can be held” even in the event in another pandemic outbreak. This precedent can assist event organizers and contribute for some extent.

Although I initially did not consider presenting the case report until several months after the event had concluded, as our studies progressed, I came to recognize the value of sharing the infection control measures we implemented from a public health perspective. Furthermore, being my first presentation at an academic conference and given that it was entirely in English, I experienced nervousness and could not deliver the presentation as smoothly as rehearsed, even in the online format. Nevertheless, the precise advice and pertinent questions from the attending doctors were greatly stimulating. I also had listened to presentations from other doctors, and I was deeply impressed by the breadth and depth of their medical knowledge and presentation skills, motivating me to strive for improvement.

Lastly, I would like to express my heartfelt gratitude to the volunteer team of “Shibuya Zunchaka!” for their involvement in implementing infection control measures, to the audience who cooperated with the measures on the day, and to Prof. Harumi Yano and Prof. Takayuki Oshimi from International University of Health and Welfare School of Medicine, who provided extensive guidance for my presentation. I extend my sincere thanks to the organizers of the ACP Japan Chapter 2023 Annual Meeting for providing me with the opportunity to present.

一般演題医学生特別賞 受賞者の言葉


ACP日本支部年次総会・講演会2023  一般演題医学生特別賞を受賞して

国際医療福祉大学医学部 大橋龍人


今回、“Successful preventive strategies for COVID-19 at the interactive festival in Shibuya, Tokyo”という演題で、2022年9月3〜4日に渋谷で開催された音楽祭「渋谷ズンチャカ!」において実施した感染対策を、症例報告という形で発表させていただきました。





Excellence Award Winner (Case Report Category)


Excellence Award (Case Report Category) Recipient’s Remarks

Yutaka Furuta, MD

Vanderbilt University Medical Center

I am honored to receive the Excellent Case Report Award at the American College of Physicians Japan Chapter Annual Meeting 2023. I shared a case of “A Medical Odyssey of a 72-Year-Old Man with Charcot-Marie-Tooth Disease Type 2 Newly Diagnosed with Biallelic Variants in SORD Gene Causing Sorbitol Dehydrogenase Deficiency.”

Sorbitol dehydrogenase (SORD) deficiency is characterized by a progressive neuropathy that results in limb weakness and difficulty walking. Previously, SORD deficiency (SORDD) was diagnosed symptomatically as an unknown subtype of Charcot-Marie-Tooth disease Type 2 (CMT2). However, very recently, biallelic variants in the SORD gene have been identified as the most common cause of undiagnosed cases of CMT2 (Cortese at al., Nat Genet. 2020). Patients who have been accurately diagnosed with SORDD have an opportunity to receive potential treatment with an investigational drug, govorestat that is currently being studied in a clinical trial (ClinicalTrials.gov Identifier: NCT05397665).

Our report describes a 72-year-old man who was referred to the Undiagnosed Diseases Network (UDN) suffering from gradual progressive weakness in both lower extremities since the age of 27. The patient was initially diagnosed as having CMT2 without a defined genetic cause. However, this patient was formally diagnosed with SORDD after the identification of homozygosity for the SORD frameshift (c.757delG:p.A253Qfs*27) through UDN Genome Sequencing. Then, the sorbitol level in his urine was found to be significantly elevated, which finally diagnosed him as having SORD deficiency.

The UDN is a research study funded by the National Institutes of Health (NIH) that strives to solve challenging medical mysteries. Vanderbilt University Medical Center is one of the original members participating the UDN, where I was given an opportunity to involve this exciting case during my residency. I gained an understanding of two important things from this case: (1) Next generation sequencing is a powerful tool to solve a medical odyssey. (2) The accurate diagnosis could provide an opportunity to receive potential treatment with an investigational drug in a clinical trial. This experience further motivated me to contribute to rare and undiagnosed diseases.

Last but not least, I would like to express my gratitude to Drs. John A Phillips and John H Newman, who have walked me through this case.



ACP日本支部年次総会・講演会2023 一般演題優秀賞(症例報告部門)を受賞して
ヴァンダービルト大学 古田 穣

この度は、ACP日本支部2023年次総会においてExcellent Case Report Awardをいただき、大変光栄に存じます。今回私が発表した症例は「2型シャルコーマリートュース病 (CMT2)と臨床診断されていたが、SORD遺伝子の両アレルフレームシフトバリアントにより、Sorbitol Dehydrogenase (SORD) Deficiencyと診断に至った一例」です。SORD deficiency (SORDD)は四肢の筋力低下を特徴とする疾患で、以前までCMT2の一つとして臨床診断されていました。しかし、2020年に、SORD遺伝子の両アレルバリアントによって起こり、さらにこのバリアントが最も多い原因であることが発見され、現在米国で治療薬の治験が行われています。

今回の症例では、下肢の筋力低下を主訴に、40年以上の間CMT2と臨床的に診断されていたものの遺伝的診断がつかず、米国Undiagnosed Diseases Network (UDN)に紹介されました。UDNとは、NIHのグラント資金で運営されている未診断や希少疾患を次世代シークエンサーなどの最先端技術を駆使して診断を導く米国の研究機関です。私が現在研修しているVanderbilt大学病院は、UDNに参加している病院の一角であり、幸運なことに今回の症例に携わることができました。長い間、原因が明かされなかった病態を最新の知見および技術で診断できたことは、まさに、”診断オデッセイ”と名づけるに相応しいと思って今回の演題を決めました。また、正しい診断がつくだけでなく、それにより治療の選択肢が生まれ得ることに、大きな意義を感じました。